Mercia Isaacs is the current executive chairperson of Vuya! investments (Pty) Ltd and the chairperson of Vuya Foundation. She began her career as a businesswoman with her husband – Samuel Isaacs – in 1978 when they started an electrical company, SMI Electrical. This was the start of Mercia's love for business.
Since then she has sat on numerous boards such as the Western Cape Gambling Board, chairperson of the Western Cape Tender Board, current chairperson of G.F. Jooste Hospital board, a board member of SHAWCO (a student-run NGO started by the University of Cape Town), non-executive board member TUV Rheinland, member of counsel at the Health Professions Counsel of South Africa (HPCSA) and on-executive director of Henkel South Africa. She has also been a member of council for Diocesan College (Bishops) for the past 4 years and sits on the advisory board for Women in Leadership at the UCT Graduate School of Business.